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LSU vs. Missouri odds, spread, line: 2023 college football picks, Week 6 predictions from proven computer

Eli Drinkwitz and the No. 21 Missouri Tigers aim to remain unbeaten on Saturday. Missouri hosts the No. 23 LSU Tigers in the sixth game of the 2023 season for both programs, and Memorial Stadium will showcase the action. Missouri is 5-0 for the first time in a decade, and Drinkwitz’s program is one of only three unbeaten units in the SEC. LSU is 3-2 overall and 2-1 against conference opponents, and this contest is one of only four games between ranked teams on the Week 6 college football schedule. 

SportsLine consensus lists LSU as a 5.5-point favorite for this noon ET kickoff. The total number of points Vegas thinks will be scored, or the over/under, is 64.5 in the latest LSU vs. Missouri odds. Before making any Missouri vs. LSU picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Missouri and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several college football odds and betting lines for Missouri vs. LSU:

  • LSU vs. Missouri spread: LSU -5.5
  • LSU vs. Missouri over/under: 64.5 points
  • LSU vs. Missouri money line: LSU -228, Missouri +185
  • LSU: 2-3 against the spread this season
  • MIZ: 3-2 against the spread this season
  • LSU vs. Missouri picks: See picks at SportsLine
  • LSU vs. Missouri live stream: fubo (try for free)

Why LSU can cover

LSU’s passing game is virtually impossible to defend. The offense is led by quarterback Jayden Daniels, who is a candidate for the Heisman Trophy. Daniels is No. 2 in FBS with 400.4 total yards per game and 16 passing touchdowns, and he ranks in the top five of the country with 342.0 passing yards per game and a 193.4 mark in passing efficiency. Daniels is completing 73.1% of his passes with only two interceptions and, in the last four games, he has 18 touchdown passes and only one interception. 

Daniels is the catalyst, but he is flanked by two elite wide receivers. Malik Nabers has 29 catches for 471 yards and four touchdowns in the last three games alone, including a 13-catch, 239-yard performance in a win over Mississippi State. On the other side, Brian Thomas is tied for the FBS lead for eight receiving touchdowns, and he has 13 catches for 257 yards and five touchdowns in the last two games. Led by the passing attack, LSU ranks in the top seven of the country in scoring offense (44.0 points per game), total offense (551.4 yards per game), yards per play (7.8) and third down efficiency (57.6%). See which team to pick here.

Why Missouri can cover

Missouri brings the better statistical defense into this matchup, including SEC-leading marks in rushing defense and yards allowed per carry. The Tigers also have a high-powered offense, however, and Missouri is averaging 32 points and 453.4 total yards per game. No SEC team is averaging more than yards per pass attempt (10.4) than Missouri, and the Tigers are generating well over seven yards per play in the last three contests. 

Quarterback Brady Cook enters this game on a streak of 348 consecutive pass attempts without an interception, the fifth-longest streak in FBS history. Cook has not thrown an interception in the last 11 games and, over that sample, he has completed 68.4% of his passes for 2,918 yards and 19 touchdowns. Cook ranks No. 2 in the SEC in passing efficiency and passing touchdowns, and he has a dynamic outside threat in receiver Luther Burden. Burden has eclipsed the 100-yard mark in four straight games, and he is in the top three in FBS in receiving yards per game (128.8) and receptions per (8.6) this season. See which team to pick here.

How to make LSU vs. Missouri picks

SportsLine’s model is leaning Under on the point total, with neither team projected to reach its season-long scoring average. The model also says one side of the spread hits in more than 50% of simulations. You can only see the model’s pick at SportsLine.

So who wins LSU vs. Missouri, and which side of the spread hits in more than 50% of simulations? Visit SportsLine now to find out which side of the LSU vs. Missouri spread you need to jump on Saturday, all from the model has generated a profit of more than $2,000 for $100 players, and find out.  

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